Cycloaddition reaction of 2-vinylazetidines with benzyne: a facile access to 1-benzazocine derivatives.

Takashi Aoki, Shunsuke Koya, Ryu Yamasaki, Shinichi Saito

Department of Chemistry, Faculty of Science, Tokyo University of Science, Kagurazaka, Shinjuku, Tokyo, 162-8601, Japan.

Organic letters 2012 Sep 7

filter terms:

The cycloaddition reaction of 2-vinylazetidines with benzyne proceeded smoothly without a catalyst, and various benzazocine derivatives were isolated in good to high yields. The scope of the reaction, as well as the reactions of other arynes, has been studied.

Citation

Takashi Aoki, Shunsuke Koya, Ryu Yamasaki, Shinichi Saito. Cycloaddition reaction of 2-vinylazetidines with benzyne: a facile access to 1-benzazocine derivatives. Organic letters. 2012 Sep 7;14(17):4506-9