A life-threatening flecainide overdose treated with intravenous fat emulsion.

Heather Ellsworth, Samuel J Stellpflug, Jon B Cole, Joseph A Dolan, Carson R Harris

Department of Emergency Medicine, Regions Hospital, St. Paul, MN 55101, USA. heatherellsworth9@gmail.com

Pacing and clinical electrophysiology : PACE 2013 Mar

filter terms:

Flecainide is a Vaughan Williams Class Ic antidysrhythmic associated with PR, QRS, and QTc prolongation on the electrocardiogram and development of life-threatening cardiac toxicity in overdose. The cornerstone of treatment is fluid resuscitation and the administration of magnesium and sodium bicarbonate. We report a case of flecainide overdose associated with life-threatening hemodynamic compromise successfully treated with intravenous fat emulsion (IFE) therapy. IFE should be considered as a novel adjunctive therapy in patients with life-threatening toxicity following flecainide overdose. ©2012, The Authors. Journal compilation ©2012 Wiley Periodicals, Inc.

Citation

Heather Ellsworth, Samuel J Stellpflug, Jon B Cole, Joseph A Dolan, Carson R Harris. A life-threatening flecainide overdose treated with intravenous fat emulsion. Pacing and clinical electrophysiology : PACE. 2013 Mar;36(3):e87-9