Clinical analysis of drug-induced Pseudo-Bartter's syndrome: a report of five cases].

To summarize the clinical characteristics and outcomes of Pseudo-Bartter's syndrome and explore its pathogenesis. The clinical data of 5 cases of Pseudo-Bartter's syndrome at our ward from May 2008 to December 2010 was analyzed retrospectively. All patients were female. Long-term regimen of purgative or diuretics was prescribed. The clinical features included normotension, hypokalemic alkalosis and activation of renin-angiotensin-aldosterone. The pathological results of 3 cases of kidney biopsy showed the hyperplasia of juxtaglomerular apparatus, thickness of arteriole, infiltration of lymphocytes and monocytes and degeneration of renal tubule. Upon a definitive diagnosis, purgative or diuretics was discontinued and supplement therapy of potassium chloride initiated. The results of laboratory tests reverted to normal ranges within 4 weeks. Purgative or diuretics should be prescribed appropriately to avoid the occurrence of Pseudo-Bartter's syndrome.

Citation

Feng-Ao Li, Hong-Yan Wei, Shan Lin, Hong-Ling Han, Ming-Cai Qiu. Clinical analysis of drug-induced Pseudo-Bartter's syndrome: a report of five cases]. Zhonghua yi xue za zhi. 2012 May 15;92(18):1278-80

Mesh Tags

Substances

PMID: 22883069

search → result