Thiazide and thiazide-like diuretics: an opportunity to reduce blood pressure in patients with advanced kidney disease.

Feras Karadsheh, Matthew R Weir

Current hypertension reports 2012 Oct

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Thiazide and thiazide-like diuretics have been widely used as blood pressure-lowering agents for more than 5 decades. However, their use in patients with advanced chronic kidney disease has been limited and often discouraged. The exact mechanism of how thiazide and thiazide-like diuretics lower blood pressures is still in question. Emerging evidence suggests that thiazides and thiazide-like diuretics are effective as blood pressure-lowering drugs in patients with advanced chronic kidney disease. Review of the literature suggests that physicians should not discard thiazide and thiazide-like diuretics as options for blood pressure management in patients with chronic advanced kidney disease.

Citation

Feras Karadsheh, Matthew R Weir. Thiazide and thiazide-like diuretics: an opportunity to reduce blood pressure in patients with advanced kidney disease. Current hypertension reports. 2012 Oct;14(5):416-20