AKT as locus of cancer multidrug resistance and fragility.

Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston Massachusetts, USA. zradisavljevic@rics.bwh.harvard.edu

Journal of cellular physiology 2013 Apr

filter terms:

Complexity and robustness of cancer hypoxic microenvironment are supported by the robust signaling networks of autocrine and paracrine elements creating powerful interactome for multidrug resistance. These elements generate a positive feedback loops responsible for the extreme robustness and multidrug resistance in solid cancer, leukemia, myeloma, and lymphoma. Phosphorylated AKT is a cancer multidrug resistance locus. Targeting that locus by oxidant/antioxidant balance modulation, positive feedback loops are converted into negative feedback loops, leading to disappearance of multidrug resistance. This is a new principle for targeting cancer multidrug resistance by the locus chemotherapy inducing a phenomenon of loops conversion. Copyright © 2012 Wiley Periodicals, Inc.