Combined effect of gemcitabine and lomustine in mice with intracranial transplanted lymphosarcoma LIO-1].

SHR mice with intracranial transplanted lymphosarcoma LIO-1 received a single intraperitoneal gemcitabine injection in maximal tolerated dose of 25 mg/kg or single maximal tolerated oral dose of lomustine, 50 mg/kg. Compared to control group gemcitabine injection increased the mice lifespan 1.4-fold (p < 0,01) and oral lomustine 1.6-fold (p < 0,01). The median lifespan of the mice receiving both gemcitabine and lomustine in maximal dose underwent a significant 3.3-fold increase (p < 0,01) compared to controls (2.4-fold compared to gemcitabine and 2.1-fold compared to lomustine group). Combined therapy didn't cause an increase of toxicity.

Citation

A N Stukov, L V Filatova, M L Gershanovich, T Iu Semiglazova, A A Tarasenkova, D Kh Latinova, S F Vershinina, N I Zargarova. Combined effect of gemcitabine and lomustine in mice with intracranial transplanted lymphosarcoma LIO-1]. Voprosy onkologii. 2012;58(3):394-7

Mesh Tags

Substances

PMID: 22888657

search → result