When the nine-membered enediynes play hide and seek.

Mickaël Jean, Sophie Tomasi, Pierre van de Weghe

Université de Rennes 1, UMR 6226, Institut des Sciences Chimiques de Rennes, Equipe PNSCM, UFR Sciences Biologiques et Pharmaceutiques, 2 avenue du Prof Léon Bernard, F-35043 Rennes Cedex, France.

Organic & biomolecular chemistry 2012 Oct 7

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The lack of stability of the 9-membered enediynes not associated with an apoprotein may explain the low number of isolated natural compounds containing this core. To overcome such a problem, particular attention should be paid during the process of extraction and isolation of secondary metabolites, especially from microorganisms such as actinomycetes in order to identify the non-cycloaromatized derivatives.

Citation

Mickaël Jean, Sophie Tomasi, Pierre van de Weghe. When the nine-membered enediynes play hide and seek. Organic & biomolecular chemistry. 2012 Oct 7;10(37):7453-6