Comparison of bone regeneration between octacalcium phosphate/collagen composite and β-tricalcium phosphate in canine calvarial defect.
Yuji Tanuma, Keiko Matsui, Tadashi Kawai, Aritsune Matsui, Osamu Suzuki, Shinji Kamakura, Seishi Echigo
Division of Oral Surgery, Department of Oral Medicine and Surgery, Graduate School of Dentistry, Tohoku University, Sendai, Japan.
Oral surgery, oral medicine, oral pathology and oral radiology 2013 JanThe present study evaluated the efficacy of bone regeneration between synthetic octacalcium phosphate (OCP) granules combined with porcine atelocollagen (OCP/Col) and β-tricalcium phosphate (β-TCP). A disk of OCP/Col (20 mm diameter, 2.5 mm thick) or commercially available sintered porous β-TCP was implanted into a critical-sized calvarial defect (20 mm diameter) of adult male canines (n = 10). The newly formed bone in the defect was analyzed radiographically, crystallographically, histologically, and histomorphometrically at 6 months after implantation. Histomorphometry showed that there was significantly more newly formed bone in OCP/Col-treated defects than for β-TCP (P < .05). X-Ray diffraction patterns of implanted OCP/Col were similar to those of original bone and different from those of implanted β-TCP. These results suggest that OCP/Col implantation in canine critical-sized defect enhanced bone regeneration more than β-TCP, which is the most commonly used synthetic bone substitutes. Copyright © 2013 Elsevier Inc. All rights reserved.
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Yuji Tanuma, Keiko Matsui, Tadashi Kawai, Aritsune Matsui, Osamu Suzuki, Shinji Kamakura, Seishi Echigo. Comparison of bone regeneration between octacalcium phosphate/collagen composite and β-tricalcium phosphate in canine calvarial defect. Oral surgery, oral medicine, oral pathology and oral radiology. 2013 Jan;115(1):9-17
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PMID: 22901651
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