Reversible thermal transition of polydiacetylene based on KTTKS collagen sequence.

Pasquale Palladino, Valeria Castelletto, Ashkan Dehsorkhi, Dmitry Stetsenko, Ian W Hamley

School of Chemistry, Food and Pharmacy, University of Reading, Reading RG6 6AD, UK.

Chemical communications (Cambridge, England) 2012 Oct 9

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Here we explore the physico-chemical properties of a peptide amphiphile obtained by chemical conjugation of the collagen-stimulating peptide KTTKS with 10,12-pentacosadiynoic acid which photopolymerizes as a stable and extended polydiacetylene. We investigate the self-assembly of this new polymer and rationalize its peculiar behavior in terms of a thermal conformational transition. Surprisingly, this polymer shows a thermal transition associated with a non-cooperative increase in β-sheet content at high temperature.

Citation

Pasquale Palladino, Valeria Castelletto, Ashkan Dehsorkhi, Dmitry Stetsenko, Ian W Hamley. Reversible thermal transition of polydiacetylene based on KTTKS collagen sequence. Chemical communications (Cambridge, England). 2012 Oct 9;48(78):9774-6