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Netrin-1 is a well-characterised chemoattractant involved in neuronal guidance in the developing enteric nervous system (ENS), but it is also a regulator of tumorigenesis. Two of its well-characterised receptors, deleted in colorectal cancer (DCC) and uncoordinated-5 homolog (UNC-5H), belong to a family of dependence receptors that transmit either pro- or anti-apoptosis signals depending on the availability of ligand, in this case netrin-1. This review summarises these two effects of netrin-1 and highlights the additional research needed information about to allow better utilisation of netrin-1 as a therapeutic target for axonal regeneration in the context of colorectal cancer. Copyright © 2012 Elsevier Ltd. All rights reserved.


Suh Youn Ko, Crispin R Dass, Kulmira Nurgali. Netrin-1 in the developing enteric nervous system and colorectal cancer. Trends in molecular medicine. 2012 Sep;18(9):544-54

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PMID: 22920895

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