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Treatment of AAV follows the principle of a combined remission induction and maintenance strategy and is adapted in a stage and activity-adapted fashion. So far the combination therapy of glucocorticoids and conventional immunosuppressive drugs has mainly been used to control disease. This approach has led to a significant improvement in outcome in spite of persistently high early mortality rates of nearly 11% within the first year. Besides conventional treatment, biologics have emerged as a new treatment option. The paper summarizes the current evidence for the use of conventional therapy and biologics in AAV. Copyright © 2012 Elsevier B.V. All rights reserved.


Julia U Holle, Wolfgang L Gross. Treatment of ANCA-associated vasculitides (AAV). Autoimmunity reviews. 2013 Feb;12(4):483-6

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PMID: 22921792

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