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We have examined several combinations of solvents with the aim of optimizing the ionization conditions for molecular diagnosis of malignant tumours by PESI-MS. Although the best conditions may depend on the actual species in the sample, the optimal conditions for renal cell carcinoma (RCC) were achieved by using alcohols. PESI-MS successfully delineated the differential expression of phospholipids (PCs) and triacylglycerols (TAGs) in noncancerous and RCC tissues by using these solvent systems. This study paves the way for the application of PESI-MS in medical samples.


Mridul Kanti Mandal, Kentaro Yoshimura, Lee Chuin Chen, Zhan Yu, Tadao Nakazawa, Ryohei Katoh, Hideki Fujii, Sen Takeda, Hiroshi Nonami, Kenzo Hiraoka. Application of probe electrospray ionization mass spectrometry (PESI-MS) to clinical diagnosis: solvent effect on lipid analysis. Journal of the American Society for Mass Spectrometry. 2012 Nov;23(11):2043-7

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PMID: 22923015

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