TRFolder-W: a web server for telomerase RNA structure prediction in yeast genomes.

Dong Zhang, Xingran Xue, Russell L Malmberg, Liming Cai

Bioinformatics (Oxford, England) 2012 Oct 15

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TRFolder-W is a web server capable of predicting core structures of telomerase RNA (TR) in yeast genomes. TRFolder is a command-line Python toolkit for TR-specific structure prediction. We developed a web-version built on the django web framework, leveraging the work done previously, to include enhancements to increase flexibility of usage. To date, there are five core sub-structures commonly found in TR of fungal species, which are the template region, downstream pseudoknot, boundary element, core-closing stem and triple helix. The aim of TRFolder-W is to use the five core structures as fundamental units to predict potential TR genes for yeast, and to provide a user-friendly interface. Moreover, the application of TRFolder-W can be extended to predict the characteristic structure on species other than fungal species. The web server TRFolder-W is available at http://rna-informatics.uga.edu/?f=software&p=TRFolder-w.

Citation

Dong Zhang, Xingran Xue, Russell L Malmberg, Liming Cai. TRFolder-W: a web server for telomerase RNA structure prediction in yeast genomes. Bioinformatics (Oxford, England). 2012 Oct 15;28(20):2696-7