Synthesis and antitumor activity evaluation of new asiatic acid derivatives.

Yan-Qiu Meng, Yun-Yun Li, Feng-Qing Li, Yan-Ling Song, Hai-Feng Wang, Hong Chen, Bo Cao

Department of Pharmaceutical Engineering, Shenyang University of Chemical Technology, Shenyang, China. mengyanqiu@hotmail.com

Journal of Asian natural products research 2012

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Twelve novel asiatic acid (AA) derivatives were designed and synthesized. Their structures were confirmed using NMR, MS, and IR spectra. Their in vitro cytotoxicities on various cancer cell lines (HeLa, HepG2, BGC-823, and SKOV3) were evaluated by the 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide assay. Most of the derivatives were found to have stronger cell growth inhibitory activity than AA. Among them, compounds 5-8 and 11 with substituted amide group at C-28 exhibited more potent cytotoxicity than AA, Gefitinib, and etoposide (positive control).

Citation

Yan-Qiu Meng, Yun-Yun Li, Feng-Qing Li, Yan-Ling Song, Hai-Feng Wang, Hong Chen, Bo Cao. Synthesis and antitumor activity evaluation of new asiatic acid derivatives. Journal of Asian natural products research. 2012;14(9):844-55