Microfabricated platforms to modulate and monitor T cell synapse assembly.

Immunological synapse (IS) is a complex supramolecular structure formed at the interface between T cells and antigen presenting cells (APCs) during T cell antigen recognition. Microfabricated platforms have made great contributions to our understanding of the assembly dynamics and functional roles of the T cell synapses over the last decade. Here, we review three different types of microfabricated platforms developed to modulate and monitor the T cell synapse assembly. Firstly, multi-protein micropatterned surfaces presenting key ligands for T cell activation that can modulate the spatial distribution of receptors/signaling molecules in T cell synapses are described. Secondly, micropatterned supported bilayers that can modulate the dynamics of T cell receptor (TCR) microclusters are introduced. Lastly, T-APC pair arrays that allow for improved fluorescence live cell imaging are discussed. Copyright © 2012 Wiley Periodicals, Inc.

Citation

Hong-Ryul Jung, Jong-Cheol Choi, Wonhwa Cho, Junsang Doh. Microfabricated platforms to modulate and monitor T cell synapse assembly. Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology. 2013 Jan-Feb;5(1):67-74

Mesh Tags

PMID: 22927231

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