Catalyst-free intramolecular oxidative cyclization of N-allylbenzamides: a new route to 2,5-substituted oxazoles.

School of Chemistry and Chemical Engineering, State Key Laboratory of Coordination, Nanjing University, Nanjing, 210093, China.

Organic letters 2012 Sep 21

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A catalyst-free intramolecular oxidative cyclization reaction of N-allylbenzamides has been developed to prepare 2,5-disubstituted oxazoles with good yields. This reaction gives an efficient synthetic strategy to form an oxazole nucleus directly from easily accessible substrates under temperate conditions.

Citation

Wei Zhou, Chen Xie, Jianlin Han, Yi Pan. Catalyst-free intramolecular oxidative cyclization of N-allylbenzamides: a new route to 2,5-substituted oxazoles. Organic letters. 2012 Sep 21;14(18):4766-9