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To identify variables associated with early nasal continuous positive airway pressure (ENCPAP) failure in preterm neonates less than 30 weeks gestational age. Multicenter prospective study including 131 preterm newborns, over a period of 2 years. Patients and respiratory variables were assessed using univariate analysis. Variables associated with ENCPAP failure were: the need of resuscitation with a FiO(2)>0.30; a CPAP pressure of 6.4±1.2 cm H(2)O; the need of a FiO(2) of 0.40 in the first 4 h of life; male gender maintaining the need of a FiO(2)>0.25 in the first 4 h of life; and respiratory distress syndrome with criteria for surfactant administration. The need for oxygen in resuscitation and maintained in first hours of life, male gender, a CPAP pressure over 5 cm H(2)O and surfactant need are predictors of ENCPAP failure in preterm neonates 26 to 30 weeks gestational age.


G Rocha, F Flôr-de-Lima, E Proença, C Carvalho, C Quintas, T Martins, A Freitas, C Paz-Dias, A Silva, H Guimarães. Failure of early nasal continuous positive airway pressure in preterm infants of 26 to 30 weeks gestation. Journal of perinatology : official journal of the California Perinatal Association. 2013 Apr;33(4):297-301

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PMID: 22935774

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