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A public-private partnership to establish biomarkers of dementia in Down's syndrome could aid the development of preventive therapies for the dementia associated with both Down's syndrome and Alzheimer's disease, based on the apparent common pathogenic role of amyloid precursor protein in the two conditions.

Citation

Seth Ness, Michael Rafii, Paul Aisen, Michael Krams, Wayne Silverman, Husseini Manji. Down's syndrome and Alzheimer's disease: towards secondary prevention. Nature reviews. Drug discovery. 2012 Sep;11(9):655-6

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PMID: 22935789

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