Enantioselective oxidation of aldehydes catalyzed by alcohol dehydrogenase.

Paul Könst, Hedda Merkens, Selin Kara, Svenja Kochius, Andreas Vogel, Ralf Zuhse, Dirk Holtmann, Isabel W C E Arends, Frank Hollmann

Department of Biotechnology, Delft University of Technology, Delft, The Netherlands.

Angewandte Chemie (International ed. in English) 2012 Sep 24

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Teaching old dogs new tricks: Alcohol dehydrogenases (ADHs) may be established redox biocatalysts but they still are good for a few surprises. ADHs can be used to oxidize aldehydes, and this was demonstrated by the oxidative dynamic kinetic resolution of profens. In the presence of a suitable cofactor regeneration system, this reaction can occur with high selectivity. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Citation

Paul Könst, Hedda Merkens, Selin Kara, Svenja Kochius, Andreas Vogel, Ralf Zuhse, Dirk Holtmann, Isabel W C E Arends, Frank Hollmann. Enantioselective oxidation of aldehydes catalyzed by alcohol dehydrogenase. Angewandte Chemie (International ed. in English). 2012 Sep 24;51(39):9914-7