Atrial reverse remodeling: restitution of early tachycardia-induced alterations of atrial ion currents after termination of rapid atrial pacing in rabbits.

Roman Laszlo, Agnes Konior, Kerstin Bentz, Christian Eick, Birgit Schreiner, Juergen Schreieck, Ralph F Bosch

Department of Cardiology, University of Tuebingen, Otfried-Mueller-Strasse 10, D-72076 Tuebingen, Germany. roman.laszlo@gmx.de

Research in veterinary science 2013 Apr

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Studies report on the reversal of electrophysiological parameters altered by atrial tachycardia after cessation of the latter. However, there is no data concerning reversal of tachycardia-induced alterations of ion currents. Reverse remodeling of atrial ion currents (I(Ca,L), I(to), I(sus)) was studied in our rabbit model of tachycardia-induced electrical remodeling. Three groups each with four animals were built. Rapid atrial pacing (600/min) for 5 days was applied in all groups. Thereafter, different time intervals (5, 10, 20 days) were awaited before the patch clamp experiments. Similar to I(to) remodeling in our model, within 20 days after cessation of atrial tachycardia, time course of I(to) reverse remodeling was also U-shaped. In contrast, there was no significant recovery of I(Ca,L) which was initially reduced by rapid atrial pacing. Relevance of a missing recovery of I(Ca,L) is likely as this current is closely linked with intracellular calcium handling. Copyright © 2012 Elsevier Ltd. All rights reserved.

Citation

Roman Laszlo, Agnes Konior, Kerstin Bentz, Christian Eick, Birgit Schreiner, Juergen Schreieck, Ralph F Bosch. Atrial reverse remodeling: restitution of early tachycardia-induced alterations of atrial ion currents after termination of rapid atrial pacing in rabbits. Research in veterinary science. 2013 Apr;94(2):320-4