Adenosine and autism: a spectrum of opportunities.

Susan A Masino, Masahito Kawamura, Jessica L Cote, Rebecca B Williams, David N Ruskin

Neuropharmacology 2013 May

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In rodents, insufficient adenosine produces behavioral and physiological symptoms consistent with several comorbidities of autism. In rodents and humans, stimuli postulated to increase adenosine can ameliorate these comorbidities. Because adenosine is a broad homeostatic regulator of cell function and nervous system activity, increasing adenosine's influence might be a new therapeutic target for autism with multiple beneficial effects. This article is part of the Special Issue entitled 'Neurodevelopmental Disorders'. Copyright © 2012 Elsevier Ltd. All rights reserved.

Citation

Susan A Masino, Masahito Kawamura, Jessica L Cote, Rebecca B Williams, David N Ruskin. Adenosine and autism: a spectrum of opportunities. Neuropharmacology. 2013 May;68:116-21