Beta-adrenergic receptor activation primes microglia cytokine production.

Exaggerated pro-inflammatory cytokine production by primed microglia is thought to mediate pathology during stress, aging, and neurodegeneration. Recently, it was demonstrated that beta-adrenergic receptor (β-AR) antagonism prevents priming of microglia in mice exposed to chronic stress. To determine if β-AR stimulation is sufficient to prime microglia, rats were intra-cerebroventricularly administered isoproterenol (β-AR agonist) or vehicle and 24 h later hippocampal microglia were placed in culture with media or LPS. Prior isoproterenol treatment significantly enhanced IL-1β and IL-6, but not TNF-α production following LPS stimulation. These data suggest that central β-AR stimulation is sufficient to prime microglia cytokine responses. Copyright © 2012 Elsevier B.V. All rights reserved.

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John D Johnson, Zachary R Zimomra, Luke T Stewart. Beta-adrenergic receptor activation primes microglia cytokine production. Journal of neuroimmunology. 2013 Jan 15;254(1-2):161-4

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PMID: 22944319

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