Chitosan matrix with three dimensionally ordered macroporous structure for nimodipine release.

Yuling Xie, Yanli Liu, Yan Wang, Siling Wang, Tongying Jiang

Department of Pharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, China.

Carbohydrate polymers 2012 Nov 6

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Three dimensionally ordered macroporous (3DOM) chitosan (3D-CS) matrix with interconnected pores in the nanometer range was developed as a drug carrier for the first time. 3D-CS was prepared using a template-assisted assembly and characterized by SEM, TGA, N(2) adsorption and FT-IR. As a model drug, nimodipine (NMDP) was incorporated into the pores of 3D-CS matrix. The solid state properties of NMDP-loaded samples were characterized by SEM, XRD, DSC and FT-IR. Dissolution studies showed that release behavior of the drug was markedly affected by the particle size of the matrix. With a relatively small matrix particle size, formulations of NMDP-3D-CS-0.5 and NMDP-3D-CS-1 exhibited rapid release patterns. However, on increasing the amount of carrier, release rate of the drug decreased. The pH-dependent slow-release characteristic of 3D-CS matrix delivery system was demonstrated by investigating the release behavior of NMDP at different pH values. Copyright © 2012 Elsevier Ltd. All rights reserved.

Citation

Yuling Xie, Yanli Liu, Yan Wang, Siling Wang, Tongying Jiang. Chitosan matrix with three dimensionally ordered macroporous structure for nimodipine release. Carbohydrate polymers. 2012 Nov 6;90(4):1648-55