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An enantioselective and convergent total synthesis of pladienolide B (1) is described. Pladienolide B binds to the SF3b complex of a spliceosome and inhibits mRNA splicing activity. The synthesis features an epoxide opening reaction, an asymmetric reduction of a β-keto ester, and a cross metathesis strategy for the side chain synthesis.


Arun K Ghosh, David D Anderson. Enantioselective total synthesis of pladienolide B: a potent spliceosome inhibitor. Organic letters. 2012 Sep 21;14(18):4730-3

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PMID: 22954141

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