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Recent interest in inactive kinase conformations has generated the need to develop new biochemical tools to study them. Here, we describe the use of a fluorescent probe that selectively and potently binds to a specific inactive conformation of protein kinases. This allows for the thermodynamics and kinetics of ligand binding to be determined.

Citation

Sanjay B Hari, Pratistha Ranjitkar, Dustin J Maly. Determination of the kinetics and thermodynamics of ligand binding to a specific inactive conformation in protein kinases. Methods in molecular biology (Clifton, N.J.). 2012;928:153-9

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PMID: 22956140

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