Enantioselective decarboxylative amination: synthesis of axially chiral allenyl amines.

State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, PR China.

Angewandte Chemie (International ed. in English) 2013 Jan 2

filter terms:

Getting axed: synthesis of the title amines, bearing functionality (R(1) and R(2)), involves the enantioselective palladium-catalyzed decarboxylation of allenyl N-tosylcarbamates. The reaction proceeds smoothly using both the chiral ligands (S)- and (R)-DTBM-Segphos (1) to afford the allenyl amines in good yields and with high enantioseletivities. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Citation

Baoqiang Wan, Shengming Ma. Enantioselective decarboxylative amination: synthesis of axially chiral allenyl amines. Angewandte Chemie (International ed. in English). 2013 Jan 2;52(1):441-5