Increased serum heat shock protein 27 antibody titers and prooxidant-antioxidant balance in patients with beta-thalassemia major.

Elham Ghahremanlu, Abdollah Banihashem, Hamidreza Saber, Shima Tavallaie, Naghmeh Mirhosseini, Majid Ghayour-Mobarhan, Gordon A A Ferns

Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Bojnurd, Iran.

Acta haematologica 2013

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Determination of the serum heat shock protein 27 (Hsp27) antibody titers and prooxidant-antioxidant balance (PAB) in patients with thalassemia as markers of cell and oxidative stress, respectively. Serum PAB and anti-Hsp27 antibody titers were measured in 140 patients with thalassemia major and 140 sex- and age-matched healthy volunteers. A significantly higher serum PAB value was observed in patients in comparison to controls. In the patient group, anti-Hsp27 antibody titers were significantly higher than for the control group (p < 0.001). We found a weak negative correlation between anti-Hsp27 antibody concentrations and the PAB (p = 0.03), but these values were not correlated with serum superoxide dismutase activity in the thalassemic patients. Increased levels of serum PAB and Hsp27 antibodies may be involved in the pathological consequences of β-thalassemia major and may contribute to the development of endothelial injury. Copyright © 2012 S. Karger AG, Basel.

Citation

Elham Ghahremanlu, Abdollah Banihashem, Hamidreza Saber, Shima Tavallaie, Naghmeh Mirhosseini, Majid Ghayour-Mobarhan, Gordon A A Ferns. Increased serum heat shock protein 27 antibody titers and prooxidant-antioxidant balance in patients with beta-thalassemia major. Acta haematologica. 2013;129(1):1-9