A novel chenodeoxycholic acid-verticinone ester induces apoptosis and cell cycle arrest in HepG2 cells.
Dong Liang, Qing Zhou, Jiuliang Zhang, Wei Gong, Chuanrui Xu, Bin Li, Yi Wang, Jiangtao Li
College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.
Steroids 2012 NovIn this study, the in vitro antitumor activity of chenodeoxycholic acid-verticinone ester (CDCA-Ver), a novel compound and its underlying mechanisms were evaluated. Results showed that CDCA-Ver significantly inhibited HepG2 cell viability in a both dose- and time-dependent manner, moreover CDCA-Ver induced apoptotic cell death and G(0)/G(1) cell cycle arrest in HepG2 cells. ROS generation, loss of balance of Bax/Bcl-2 ratio, loss of mitochondrial transmembrane potential, activation of caspases and elevation of intracellular free Ca(2+) concentration were involved in the CDCA-Ver induced apoptosis pathway in HepG2 cells. We concluded that CDCA-Ver may be a potential candidate for the therapy of cancer. Copyright © 2012 Elsevier Inc. All rights reserved.
Citation
Dong Liang, Qing Zhou, Jiuliang Zhang, Wei Gong, Chuanrui Xu, Bin Li, Yi Wang, Jiangtao Li. A novel chenodeoxycholic acid-verticinone ester induces apoptosis and cell cycle arrest in HepG2 cells. Steroids. 2012 Nov;77(13):1381-90
Mesh Tags
Substances
PMID: 22974827
View Full Text
