Setting sail for glucose homeostasis with the AKAP150-PP2B-anchor.
Adrian Kee Keong Teo, Rohit N Kulkarni
Section of Islet Cell Biology and Regenerative Medicine, Joslin Diabetes Center and Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
The EMBO journal 2012 Oct 17Glucose-stimulated insulin secretion, controlled by multiple protein phosphorylation events, is critical for the regulation of glucose homeostasis. Protein kinase A (PKA) is known to play a role in β cell physiology, but the role of its anchoring protein is not fully understood. Hinke et al (2012) illustrate the significance of A-kinase anchoring protein 150 in tethering protein phosphatase 2B to mediate nutrient-stimulated insulin secretion and thus modulate glucose homeostasis.
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Adrian Kee Keong Teo, Rohit N Kulkarni. Setting sail for glucose homeostasis with the AKAP150-PP2B-anchor. The EMBO journal. 2012 Oct 17;31(20):3956-7
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PMID: 22983555
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