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Glucose-stimulated insulin secretion, controlled by multiple protein phosphorylation events, is critical for the regulation of glucose homeostasis. Protein kinase A (PKA) is known to play a role in β cell physiology, but the role of its anchoring protein is not fully understood. Hinke et al (2012) illustrate the significance of A-kinase anchoring protein 150 in tethering protein phosphatase 2B to mediate nutrient-stimulated insulin secretion and thus modulate glucose homeostasis.

Citation

Adrian Kee Keong Teo, Rohit N Kulkarni. Setting sail for glucose homeostasis with the AKAP150-PP2B-anchor. The EMBO journal. 2012 Oct 17;31(20):3956-7

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PMID: 22983555

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