Occludin dislocation in brain capillary endothelium of rats with bile duct ligation induced cholestasis.

Adamantios G Mavrakis, Sophia Havaki, Evangelos Marinos, Elisabeth Chroni, Dimitris Konstantinou

Department of Neurosurgery, School of Medicine, University of Patras, Patras, Greece.

Neuroscience letters 2012 Oct 24

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The present study used a rat model with bile duct ligation to examine the effect of cholestasis, to the localization of occludin in brain capillary endothelium by means of electronic microscopy. The results demonstrated a dislocation of occludin away from the tight junction sites of brain endothelial cells. A significant increase of the occludin-interendothelial cleft distance was demonstrated in the midbrain and the cerebellum samples but not in the frontal cortex, compared to the control group samples. These findings imply a brain region selective derangement of occludin in response to liver disease. Copyright © 2012. Published by Elsevier Ireland Ltd.

Citation

Adamantios G Mavrakis, Sophia Havaki, Evangelos Marinos, Elisabeth Chroni, Dimitris Konstantinou. Occludin dislocation in brain capillary endothelium of rats with bile duct ligation induced cholestasis. Neuroscience letters. 2012 Oct 24;528(2):180-4