Relevance of long non-coding RNAs in tumour biology].

Zoltán Nagy, Diána Rita Szabó, Adrienn Zsippai, András Falus, Károly Rácz, Péter Igaz

Semmelweis Egyetem, Általános Orvostudományi Kar II. Belgyógyászati Klinika Budapest.

Orvosi hetilap 2012 Sep 23

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The discovery of the biological relevance of non-coding RNA molecules represents one of the most significant advances in contemporary molecular biology. It has turned out that a major fraction of the non-coding part of the genome is transcribed. Beside small RNAs (including microRNAs) more and more data are disclosed concerning long non-coding RNAs of 200 nucleotides to 100 kb length that are implicated in the regulation of several basic molecular processes (cell proliferation, chromatin functioning, microRNA-mediated effects, etc.). Some of these long non-coding RNAs have been associated with human tumours, including H19, HOTAIR, MALAT1, etc., the different expression of which has been noted in various neoplasms relative to healthy tissues. Long non-coding RNAs may represent novel markers of molecular diagnostics and they might even turn out to be targets of therapeutic intervention.

Citation

Zoltán Nagy, Diána Rita Szabó, Adrienn Zsippai, András Falus, Károly Rácz, Péter Igaz. Relevance of long non-coding RNAs in tumour biology]. Orvosi hetilap. 2012 Sep 23;153(38):1494-501