Ring-closing metathesis/isomerization/Pictet-Spengler cascade via ruthenium/chiral phosphoric acid sequential catalysis.

Quan Cai, Xiao-Wei Liang, Shou-Guo Wang, Jun-Wei Zhang, Xiao Zhang, Shu-Li You

State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, China.

Organic letters 2012 Oct 5

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Chiral phosphoric acid worked together with Hoveyda-Grubbs II catalyst enabling highly efficient synthesis of enantioenriched tetrahydro-β-carbolines (up to 98% yield, 99% ee) through a ring-closing metathesis/isomerization/Pictet-Spengler cascade reaction via sequential catalysis.

Citation

Quan Cai, Xiao-Wei Liang, Shou-Guo Wang, Jun-Wei Zhang, Xiao Zhang, Shu-Li You. Ring-closing metathesis/isomerization/Pictet-Spengler cascade via ruthenium/chiral phosphoric acid sequential catalysis. Organic letters. 2012 Oct 5;14(19):5022-5