Levetiracetam-associated aggravation of myoclonic seizure in children.

Yong-Hong Liu, Xiao-Li Wang, Yan-Chun Deng, Gang Zhao

Department of Neurology, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, PR China. liuyhong@fmmu.edu.cn

Seizure : the journal of the British Epilepsy Association 2012 Dec

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Some antiepileptic drugs (AEDs) have been reported to aggravate generalized seizures. We have seen three children whose myoclonic seizures increased on starting treatment with Levetiracetam. In all seizures aggravation was temporally associated to the introduction of the drug. All became seizure-free on withdrawal of levetiracetam with a switch to an alternative antiepileptic drug and this persisted for at least 6 months. This suggests that some children with myoclonic seizures may have an aggravation on starting treatment with levetiracetam but this requires further studies. Copyright © 2012 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.

Citation

Yong-Hong Liu, Xiao-Li Wang, Yan-Chun Deng, Gang Zhao. Levetiracetam-associated aggravation of myoclonic seizure in children. Seizure : the journal of the British Epilepsy Association. 2012 Dec;21(10):807-9