The in vivo antimalarial activity of methylene blue combined with pyrimethamine, chloroquine and quinine.

The effectiveness of methylene blue (MB) combined with pyrimethamine (PYR), chloroquine (CQ) or quinine (Q) was examined in a classical four-day suppressive test against a causative agent of rodent malaria, Plasmodium berghei. A marked potentiation was observed when MB was administered at a non-curative dose of 15 mg/kg/day in combination with PYR (0.19 mg/kg/day) or Q (25 mg/kg/day). No synergy was found between MB (15 mg/Kg) and CQ (0.75 mg/Kg). Our results suggest that the combination of MB with PYR or Q may improve the efficacy of these currently used antimalarial drugs.

Citation

Giovanny Garavito, Stéphane Bertani, Miguel Quiliano, Alexis Valentin, Ignacio Aldana, Eric Deharo. The in vivo antimalarial activity of methylene blue combined with pyrimethamine, chloroquine and quinine. Memórias do Instituto Oswaldo Cruz. 2012 Sep;107(6):820-3

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PMID: 22990975

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