Total synthesis of cyclocitropside A and its conversion to cyclocitropsides B and C via asparagine deamidation.

Robert E Thompson, Richard J Payne, Katrina A Jolliffe

School of Chemistry, The University of Sydney, NSW 2006, Australia.

Organic letters 2012 Oct 5

filter terms:

The total syntheses of three closely related cyclic peptide natural products, cyclocitropsides A-C, are described. Cyclocitropside A could be readily converted into cyclocitropsides B and C through an asparagine deamidation pathway, indicating that this is a plausible biosynthetic route to these compounds.

Citation

Robert E Thompson, Richard J Payne, Katrina A Jolliffe. Total synthesis of cyclocitropside A and its conversion to cyclocitropsides B and C via asparagine deamidation. Organic letters. 2012 Oct 5;14(19):5110-3