Synthesis of benzimidazoles by PIDA-promoted direct C(sp2)-H imidation of N-arylamidines.
Jinbo Huang, Yimiao He, Yong Wang, Qiang Zhu
State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, China.
Chemistry (Weinheim an der Bergstrasse, Germany) 2012 Oct 29A metal-free synthesis of diversified benzimidazoles from N-arylamidines through a phenyliodine(III) diacetate (PIDA) promoted intramolecular direct C(sp(2))-H imidation has been developed. The reaction proceeds smoothly at 0 °C or ambient temperature to provide the desired products in good to excellent yields. The synthesis of 2-alkyl- or 2-alkyl-fused benzimidazoles, which are generally inaccessible by similar Pd- or Cu-catalyzed approaches, can also be achieved. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Citation
Jinbo Huang, Yimiao He, Yong Wang, Qiang Zhu. Synthesis of benzimidazoles by PIDA-promoted direct C(sp2)-H imidation of N-arylamidines. Chemistry (Weinheim an der Bergstrasse, Germany). 2012 Oct 29;18(44):13964-7
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PMID: 22996950
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