Pd(0)-catalyzed decarboxylative coupling and tandem C-H arylation/decarboxylation for the synthesis of heteroaromatic biaryls.
Debkumar Nandi, Yang-Ming Jhou, Jhen-Yi Lee, Bing-Chiuan Kuo, Chien-Yu Liu, Pei-Wen Huang, Hon Man Lee
Department of Chemistry, National Changhua University of Education, Changhua 50058, Taiwan, R.O.C.
The Journal of organic chemistry 2012 Oct 19An effective Pd(0) carbene complex was successfully employed in the decarboxylative coupling of the heteroaromatic carboxylic acids (imidazo[1,2-a]pyridine and isoxazole) with aryl halides. For carboxyindoles, either decarboxylative coupling or tandem C-H arylation and decarboxylation occurred, leading to the formation of C2-monoarylated indoles.
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Debkumar Nandi, Yang-Ming Jhou, Jhen-Yi Lee, Bing-Chiuan Kuo, Chien-Yu Liu, Pei-Wen Huang, Hon Man Lee. Pd(0)-catalyzed decarboxylative coupling and tandem C-H arylation/decarboxylation for the synthesis of heteroaromatic biaryls. The Journal of organic chemistry. 2012 Oct 19;77(20):9384-90
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PMID: 22998080
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