Autophagic lysosome reformation.

State Key Laboratory of Biomembrane and Membrane Biotechnology, Tsinghua University-Peking University Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China.

Experimental cell research 2013 Jan 15

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Autophagy is an evolutionarily conserved lysosome-dependent degradation pathway. In recent years, many important advances have been made in understanding the cellular and molecular mechanism of autophagosome formation. However, the late stages of autophagy-the cellular events after formation of the autolysosome-are relatively rarely studied. In this review, we discussed the cellular process and molecular mechanism of autophagic lysosome reformation, a cellular events which defines the terminal stage of autophagy. Copyright © 2012 Elsevier Inc. All rights reserved.