The potential nephrotoxicity of antiretroviral drugs].

 The intensive studies carried out in many scientific laboratories and the efforts of numerous pharmaceutical companies have led to the development of drugs which are able to effectively inhibit HIV proliferation. At present, a number of antiretroviral agents with different mechanisms of action are available. Unfortunately, long-term use of antiretroviral drugs, however, does not remain indifferent to the patient and can cause significant side effects. In the present work, the antiretroviral drugs with a nephrotoxicity potential most commonly used in clinical practice are described. In the review attention has also been focused on the nephropathy resulting from the HIV infection alone and the influence of genetic factors on the occurrence of pathological changes in the kidney.

Citation

Zofia Marchewka, Beata Szymańska, Joanna Płonka. The potential nephrotoxicity of antiretroviral drugs]. Postȩpy higieny i medycyny doświadczalnej (Online). 2012;66:603-8

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PMID: 23001202

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