An engineered lantipeptide synthetase serves as a general leader peptide-dependent kinase.

Phosphorylation is an abundant post-translational modification involved in a myriad of cell signaling pathways. Herein, we have engineered the class II lantipeptide synthetase ProcM to generate a variety of peptides containing O-phosphoserine (pSer) and O-phosphothreonine (pThr) residues, either in vitro or in vivo.

Citation

Gabrielle N Thibodeaux, Wilfred A van der Donk. An engineered lantipeptide synthetase serves as a general leader peptide-dependent kinase. Chemical communications (Cambridge, England). 2012 Nov 07;48(86):10615-7

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PMID: 23001385

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