Saba Ahmad, Muhammad Akhyar Farrukh
Department of Chemistry, Government College University Lahore, Lahore, Pakistan.
Pakistan journal of pharmaceutical sciences 2012 OctSulfonamides, being the member of the oldest anti-microbial group of compounds possess wide anti-microbial activities and are effective against pathogenic strains of gram-positive and gram-negative bacteria. They are widely used in the treatment of various infectious diseases e.g. malaria, urinary tract infections, respiratory tract infections etc. Based on their effectiveness against most of the bacteria, two novel sulfonamides (N-(2-methoxy phenyl)-4-methylbenzenesulfonamide and N-ethyl-4-methyl-N-(3-methyl phenyl)benzenesulfonamide) were synthesized. The compounds were characterized by FT-IR and elemental analyzer. Their anti-microbial activity was assessed and observed against gram-positive and gram-negative bacteria using disc diffusion method. They showed good anti-microbial activities.
Saba Ahmad, Muhammad Akhyar Farrukh. Anti-microbial activities of sulfonamides using disc diffusion method. Pakistan journal of pharmaceutical sciences. 2012 Oct;25(4):839-44
PMID: 23010002
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