Intravenous infusion of hyperosmotic NaCl solution induces acute cor pulmonale in anesthetized rats.

Chikara Abe, Yoshiharu Tsuru, Chihiro Iwata, Ryosuke Ogihara, Hironobu Morita

The journal of physiological sciences : JPS 2013 Jan

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Intravenous hyperosmotic NaCl infusion is an effective treatment for circulatory shock. However, a fast infusion rate (2 mL/kg at the rate of 1 mL/s) induces transient hypotension. This response has been reported to be due to decreased total peripheral resistance and/or decreased cardiac performance. Although the hypotension is transient and recovers within 2 min without detrimental consequences, it is important to understand the associated hemodynamics and mechanisms. We found that the hypotensive effect was larger with intravenous NaCl infusion than with intra-aortic infusion, indicating that change in cardiac performance played a more significant role than change in peripheral resistance. NaCl infusion induced an increase in pulmonary vascular resistance and central venous pressure and a decrease in right ventricular dP/dt max, suggesting acute cor pulmonale. Diastolic ventricular crosstalk-induced left ventricular failure was also observed. Hyperosmotic NaCl-induced hypotension was therefore mainly due to a combination of acute cor pulmonale and left ventricular failure.

Citation

Chikara Abe, Yoshiharu Tsuru, Chihiro Iwata, Ryosuke Ogihara, Hironobu Morita. Intravenous infusion of hyperosmotic NaCl solution induces acute cor pulmonale in anesthetized rats. The journal of physiological sciences : JPS. 2013 Jan;63(1):55-62