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We previously showed that the preservation of neural adhesion molecule (NCAM) in differentiated thyroid carcinoma is an important indicator for a higher risk of distant metastasis. In the present study, we further demonstrated that forced NCAM-140 isoform expression in human thyroid cancer cells could lead to aggressive growth by enhancing migration and anchorage-independent growth, and exhibiting partial features of epithelial mesenchymal transition. More extensive distant metastasis was also noted in an animal xenograft model when NCAM-expressing thyroid cancer cells were introduced into mice intravascularly. Bioinformatic analysis of NCAM-associated expression profiles predicted a highly interactive protein network, which further implies potential molecular mechanisms underlying the metastatic processes of thyroid cancer.


An-Hang Yang, Yat-Pang Chau, Chen-Hsen Lee, Jui-Yu Chen, Jun-Yi Chen, Chien-Chih Ke, Ren-Shyan Liu. The influence of neural cell adhesion molecule isoform 140 on the metastasis of thyroid carcinoma. Clinical & experimental metastasis. 2013 Mar;30(3):299-307

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PMID: 23015367

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