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Individual differences in response to pharmacologic treatment limits the usefulness of mean data obtained from randomized controlled trials. These individual differences exist even in genetically uniform inbred mouse strains. While stratification can be of value in large studies, the individual patient history is the most effective currently available guide for personalized medicine in psychopharmacology.

Citation

Rh Belmaker, Yuly Bersudsky, Galila Agam. Individual differences and evidence-based psychopharmacology. BMC medicine. 2012;10:110

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PMID: 23016518

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