IQGAP1: A microtubule-microfilament scaffolding protein with multiple roles in nerve cell development and synaptic plasticity.

Ignacio Jausoro, Iván Mestres, Mónica Remedi, Mónica Sanchez, Alfredo Cáceres

Laboratory of Neurobiology, Instituto Investigación Médica Mercedes y Martín Ferreyra (INIMEC-CONICET), Córdoba, Argentina.

Histology and histopathology 2012 Nov

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In this article, we review our current understanding of the biology of IQ domain-containing GTPase-Activating Protein 1, IQGAP1, a scaffolding protein with multiple binding partners, which is widely expressed among different cell types, including neurons, and capable of linking Rho-GTPase signaling with cytosleletal elements and environmental cues. Interestingly, a series of recent studies suggest that IQGAP family members have an important role in neuronal development, synaptic plasticity and nervous system disorders involving alterations in spine density.

Citation

Ignacio Jausoro, Iván Mestres, Mónica Remedi, Mónica Sanchez, Alfredo Cáceres. IQGAP1: A microtubule-microfilament scaffolding protein with multiple roles in nerve cell development and synaptic plasticity. Histology and histopathology. 2012 Nov;27(11):1385-94