Xi-Mei Zhang, Ye-Xiong Li, Wei-Hu Wang, Jing Jin, Shu-Lian Wang, Yue-Ping Liu, Yong-Wen Song, Hui Fang, Hua Ren, Li-Qiang Zhou, Xin-Fan Liu, Zi-Hao Yu
Department of Radiation Oncology, Cancer Hospital and Institution, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, PR China.
International journal of radiation oncology, biology, physics 2013 Mar 15Early stage peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS) is rare. The purpose of this study was to evaluate the outcome of treatment as well as the potential role of radiation therapy in PTCL-NOS. Thirty-five patients with early stage PTCL-NOS were included. There were 13 patients with stage I disease and 22 with stage II. All patients except 1 received doxorubicin-based chemotherapy alone (n=13) or a combination of chemotherapy and radiation therapy (CMT) (n=21). The 3-year overall survival (OS) and progression-free survival (PFS) rates for the entire group were 41.3% and 25.7%, respectively. The addition of radiation therapy to chemotherapy significantly improved OS and PFS in early stage PTCL-NOS. The 3-year OS and PFS rates were 49.7% and 33.3% for CMT, compared with 23.1% (P=.042) and 15.4% (P=.035) for chemotherapy alone, respectively. The prognosis for patients who achieved a complete response (CR) was significantly better than that observed in those who did not achieve a CR. Despite the aggressive clinical course of early stage PTCL-NOS, additional radiation therapy has a significant impact on outcome. The integration of local radiation therapy into more effective systemic therapies may further improve survival. Crown Copyright © 2013. Published by Elsevier Inc. All rights reserved.
Xi-Mei Zhang, Ye-Xiong Li, Wei-Hu Wang, Jing Jin, Shu-Lian Wang, Yue-Ping Liu, Yong-Wen Song, Hui Fang, Hua Ren, Li-Qiang Zhou, Xin-Fan Liu, Zi-Hao Yu. Survival advantage with the addition of radiation therapy to chemotherapy in early stage peripheral T-cell lymphoma, not otherwise specified. International journal of radiation oncology, biology, physics. 2013 Mar 15;85(4):1051-6
PMID: 23021436
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