Total synthesis of (29S,37S)-isomer of malevamide E, a potent ion-channel inhibitor.

Praveen Kumar Gajula, Shrikant Sharma, Ravi Sankar Ampapathi, Tushar Kanti Chakraborty

CSIR-Central Drug Research Institute, Lucknow-226 001, India.

Organic & biomolecular chemistry 2013 Jan 14

filter terms:

The first total synthesis of (29S,37S)-malevamide E (1), a potent ion channel inhibitor, has been achieved in a convergent fashion involving Julia-Kocienski olefination, Urpi acetal aldol and Shiina macrolactonization reactions as the key steps. The strategy developed herein is amenable for the synthesis of the other possible isomers in search for the correct stereoisomer of the naturally occurring molecule.

Citation

Praveen Kumar Gajula, Shrikant Sharma, Ravi Sankar Ampapathi, Tushar Kanti Chakraborty. Total synthesis of (29S,37S)-isomer of malevamide E, a potent ion-channel inhibitor. Organic & biomolecular chemistry. 2013 Jan 14;11(2):257-60