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A novel surface-enhanced Raman scattering (SERS) assay is demonstrated by developing a cross strand-displacement amplification (CSDA) method to enhance the SERS signals. Highly sensitive and selective detection of any single-stranded DNA is achieved and an aptasensor for proteins is constructed.


Ying Li, Chengcun Lei, Yan Zeng, Xiaoting Ji, Shusheng Zhang. Sensitive SERS detection of DNA and lysozyme based on polymerase assisted cross strand-displacement amplification. Chemical communications (Cambridge, England). 2012 Nov 14;48(88):10892-4

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PMID: 23033199

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