Propargyl Claisen rearrangement: allene synthesis and beyond.

David Tejedor, Gabriela Méndez-Abt, Leandro Cotos, Fernando García-Tellado

Instituto de Productos Naturales y Agrobiología, CSIC, Astrofísico Francisco Sánchez 3, 38206 La Laguna, Tenerife, Canary Islands, Spain. dtejedor@ipna.csic.es

Chemical Society reviews 2013 Jan 21

filter terms:

The propargyl Claisen rearrangement is a known protocol to gain access to functionalized allenes through the [3,3]-sigmatropic transformation of propargyl vinyl ethers. The correct use of appropriate propargyl vinyl ethers as starting materials coupled with suitable reaction conditions can aid in the development of new domino methodologies in which the allenes are valuable intermediates in route to a wide range of important classes of organic compounds.

Citation

David Tejedor, Gabriela Méndez-Abt, Leandro Cotos, Fernando García-Tellado. Propargyl Claisen rearrangement: allene synthesis and beyond. Chemical Society reviews. 2013 Jan 21;42(2):458-71