Isotope-based analysis of modified tRNA nucleosides correlates modification density with translational efficiency.

Angewandte Chemie (International ed. in English) 2012 Oct 29

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Useful diversity: Quantification of modified tRNA nucleobases in different murine and porcine tissues reveals a tissue-specific overall modification content. The modification content correlates with rates of protein synthesis in vitro, suggesting a direct link between tRNA modification levels and tissue-specific translational efficiency. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Citation

Caterina Brandmayr, Mirko Wagner, Tobias Brückl, Daniel Globisch, David Pearson, Andrea Christa Kneuttinger, Veronika Reiter, Antje Hienzsch, Susanne Koch, Ines Thoma, Peter Thumbs, Stylianos Michalakis, Markus Müller, Martin Biel, Thomas Carell. Isotope-based analysis of modified tRNA nucleosides correlates modification density with translational efficiency. Angewandte Chemie (International ed. in English). 2012 Oct 29;51(44):11162-5